Sumo interaction motif
Webmodifier (SUMO) plays essential roles in eukaryotic growth and development. Many covalently modified SUMO targets have been identified; however, the extent and … Web2 Oct 2012 · The stimulation is brought about by a SUMO-interacting motif in Rad18, which also mediates sumoylation of Rad18 itself. Our results imply that sumoylated PCNA is the physiological ubiquitylation target of budding yeast Rad18 and suggest a new mechanism by which the transition from S phase-associated sumoylation to damage-induced …
Sumo interaction motif
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WebThe interaction between Srs2 and SUMO has been suggested to be mediated by a SIM motif comprising the last five amino acids of the protein. Supporting this notion, deletion of this … WebDisruption of either WRKY33 SUMO or MPK3/6 SIM sites attenuates their interaction and inactivates WRKY33-mediated defense. However, MPK3/6 SIM mutants show normal …
Web19 Jan 2024 · S100A1 is a small EF-type Ca2+ sensor protein that belongs to the multigenic S100 protein family. It is abundantly expressed in cardiomyocytes (CMs) and has been … Web1 Sep 2024 · Small ubiquitin-like modifiers (SUMOs) are tiny but important protein regulators involved in orchestrating a broad spectrum of biological processes, either by covalently modifying protein substrates, or by non-covalently interacting with other …
WebSUMO-1 (small ubiquitin-related modifier; also known as PIC1, UBL1, Sentrin, GMP1, and Smt3) is a member of the ubiquitin and ubiquitin-like superfamily. Most SUMO-modified …
Web22 Apr 2013 · Non-covalent interactions with SUMO can also occur through SIMs (SUMO interacting motifs). ... T. G. & Chen, Y. Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proceedings of the National Academy of Sciences of the United States of America 101, 14373–8 (2004). [PMC free article] [Google Scholar]
Web21 Oct 2024 · However, an NMR chemical shift perturbation study showed that the Ser-X-Ser motif was not required for binding to SUMO [although, as discussed below, it does play a … pine bluff shores swansboro ncWeb2 Jul 2015 · SUMO creates an interface for the recruitment of protein cofactors that harbor short peptide sequences known as SUMO-interacting motifs (SIMs). Most SIMs feature a … pine bluff simmons bankWeb11 Oct 2010 · This Ψ-K-X-E/D motif is enriched in targets of SUMOylation, and lysine (K) is the residue targeted for SUMO modification in those proteins [26,27]. Notably, of the 13 proteins with kinetic defects in interaction affinity for mei4∆ct , 7 (54%) carry the SUMOylation motif with 5/7 possessing the most common form Y/L-K-X-E. pine bluff shotWeb25 Oct 2024 · The affinity between these two subunits was lower in siz1-2 cells than in wild-type cells , which is consistent with the conclusion that the SUMOylation of NF-YC10 is … top michelin tireWebtion of SUMO-SIM interactions. SUMO proteins are small ubiquitin (Ub)5-related modifiers that become conjugated to cellular substrates and regulate diverse cellular … top michigan online casinosWebCovalent Modification of p73aby SUMO-1 TWO-HYBRID SCREENING WITH p73 IDENTIFIES NOVEL SUMO-1-INTERACTING PROTEINS AND A SUMO-1 INTERACTION MOTIF* Received for publication, May 18, 2000, and in ... top michigan pontiac car insuranceWeb22 Jul 2014 · It has been established that residues constituting this SUMO consensus motif interact directly with the E2 SUMO-conjugating enzyme (reviewed in ref. 2 ). For SUMO sites located in such a motif, we observed a marked preference for valine or isoleucine for the hydrophobic residue preceding the modified lysine ( Fig. 4 C ). top michigan medical malpractice law firms