WebOct 10, 2024 · Self-amplifying RNA (SaRNA) is a burgeoning platform that exploits the replication machinery of alphaviruses such as Venezuelan equine encephalitis (VEE) virus or Sindbis virus (SIN). SaRNA has been used for development of human vaccines, but has not been evaluated for porcine vaccine development. WebJan 1, 2015 · Self-amplifying mRNA vaccines have attractive features that are lacking in nonamplifying mRNA vaccines, such as the autoreplicative ability resulting in high levels of expression of the encoded vaccine antigen in host cells, regardless of cell division.
Amplifying RNA Vaccine Development NEJM
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