Receptor lipophagy
Webb3 mars 2024 · Studies with receptor-selective agonists revealed that oxysterol receptors (LXRs) and the bile acid receptor, FXR, are the RXR heterodimeric partners that mediate these effects by regulating expression of the reverse-cholesterol transporter, ABC1 ( 600046 ), and the rate-limiting enzyme of bile acid synthesis, CYP7A1, respectively. Webb7 dec. 2024 · Lipophagy, the selective engulfment of lipid droplets (LDs) by autophagosomes for lysosomal degradation, is critical to lipid and energy homeostasis. …
Receptor lipophagy
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WebbCreated an in vitro model of inflammation mediated by mitochondrial fragmentation in microglia from transgenic mice for a EU collaborative project Set up instrumentation for measuring live cell... Webb8 feb. 2024 · Lipophagy: a novel type of lipid catabolism Lipid metabolism is a complex metabolic process that includes digestion, absorption, synthesis, catabolism and …
WebbDr Sovan Sarkar is a Birmingham Fellow (equivalent to Assistant Professor) at the University of Birmingham, and holds the distinction of Former Fellow for life at Hughes Hall, University of Cambridge. He studies the biological process of autophagy, which is an intracellular degradation pathway essential for cellular survival. Utilizing human … WebbTo initiate lipophagy, Rab7, a small GTPase belonging to a large superfamily of Ras-like GTPases, has been presumed to be an essential and crucial organizer, directing membrane fusion between LDs-loaded autophagosomes and lysosomes with the assistance of soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins …
WebbKVIR_12_1996059 - Read online for free. Pathogenesis and virulence of flavivirus infections
Webblipophagy by inducing the recruitment of triglycerides and sterol esters, directly contributing to the formation of auto-phagosome (Shpilka et al., 2015; Ward et al., 2016). …
Webb7 okt. 2024 · Apart from polyubiquitination as a signal for specific autophagic degradation of LDs, autophagy selective receptors may also be involved in conferring selectivity to … tryout announcementWebband primary neurons [39,40]. The latter observation suggests that lipophagy is implicated in the pathology of HD. A more direct link between Htt and lipophagy was reported by Rui … try out asesmen nasionalWebbThe diagram shows two classical mitophagy pathways: (1) mitophagy receptors/adapters-mediated mitophagy and (2) PINK1/Parkin-induced mitophagy. (1) Under hypoxic … phillipian 2:1-13 commentaryWebb1 okt. 2024 · LD-localized receptors for lipophagy A great deal of interest has focused on the identification of cargo-specific selective autophagy receptors that may provide … phillip hylanderWebbHere we show that GPR120, a receptor for polyunsaturated fatty acids, promotes brown fat activation. Using RNA-seq to analyse mouse BAT transcriptome, we find that the gene encoding GPR120 is induced by thermogenic activation. ... brown adipocytes show signs of active lipophagy, which is suppressed by a cAMP-mediated thermogenic stimulus. phillip hutchinson bank robberWebbOriginally described in yeast cells, "lipophagy" refers to the degradation of LDs by autophagy. Yet, how LDs are targeted for autophagy is poorly defined. Here, we … phillip hymanWebb极低密度脂蛋白受体 (VLDLR)重组蛋白 Recombinant Very Low Density Lipoprotein Receptor (VLDLR) VLDL-R 信号转导 代谢通路 内分泌学 心脑血管 肝胆病学 编号RPB009Hu01 物种Homo sapiens (Human，人) 相同的名称，不同的物种。 来源原核表达 宿主E.coli 内毒素水平<1.0EU/µg (LAL法测定) 亚细胞定位Membrane, clathrin-coated … try out bard