Parkin co-regulated protein
Web21 Aug 2009 · The Parkin Co-Regulated Gene (PACRG) encodes a predicted protein of 257 amino acids that displays considerable evolutionary conservation among metazoan and protozoan species.PACRG is physically and functionally linked to the Parkinson's disease (PD) associated gene parkin.In addition to being oriented in a head-to-head arrangement … Web7 Apr 2024 · Doxorubicin (DOX) has been recognized as one of the most effective chemotherapies and extensively used in the clinical settings of human cancer. However, DOX-mediated cardiotoxicity is known to compromise the clinical effectiveness of chemotherapy, resulting in cardiomyopathy and heart failure. Recently, accumulation of …
Parkin co-regulated protein
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WebIPR019399 Parkin_co-regulated_protein; PANTHER. PTHR21207 PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED 1 hit; Pfam. View protein in Pfam; PF10274 ParcG 1 hit; SUPFAM. SSF48371 ARM repeat 1 hit; MobiDB. WebInterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool. InterPro
Web4 Feb 2024 · The Parkin-coregulated gene ( PACRG ), which encodes a protein of unknown function, shares a bidirectional promoter with Parkin ( PRKN ), which encodes an E3 … Web27 Jan 2010 · Abstract. The quaking viable mouse (qk v) is a spontaneous recessive mouse mutant with a deletion of ∼1.1 Mb in the proximal region of chromosome 17.The deletion affects the expression of three genes; quaking (Qk), Parkin-coregulated gene (Pacrg) and parkin (Park2).The resulting phenotype, which includes dysmyelination of the central …
Web9 Jul 2012 · Parkin Promotes Degradation of the Mitochondrial Pro-Apoptotic ARTS Protein Parkinson’s disease (PD) is associated with excessive cell death causing selective loss of dopaminergic neurons. Dysfunction of the Ubiquitin Proteasome System (UPS) is associated with the pathophysiology of PD. Web7 Nov 2014 · Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1. Journal of Neurochemistry Apr 2010 Abnormal iron accumulation is linked to a...
WebAs mitochondrial dynamics and morphology regulation are critical for their function, next, we analyzed the expression levels of fusion and fission proteins. Our data revealed the up-regulation of the main three genes associated with mitochondrial fusion, with increased levels of mRNA for Mfn1 , Mfn2 , and Opa1 ( p = 0.001, p = 0.0135, and p = 0.0274 …
Web1 Jul 2009 · PArkin Co-Regulated Gene is a gene that shares a bidirectional promoter with the Parkinson's disease associated gene parkin. The encoded protein (PACRG) is found in Lewy bodies and glial cytoplasmic inclusions, the … christian schools near clarksville tnWeb9 Apr 2024 · We confirmed the parkin RBR E3 ubiquitin protein ligase (also called Parkin or PRKN) and PRDX6 interaction in hepatocytes by co-immunoprecipitation (Supplementary Fig. 9A). To reveal the relationship among Miz1, PRDX6 and Parkin, immunoprecipitation in the WDF-induced NASH model showed that Parkin interacted with PRDX6 at 8 weeks and … georgia tipped minimum wageWebThe parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also … christian schools near dayton ohioWebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules) christian schools near harrisburg paWebParkin coregulated gene protein Alternative Names PACRG; GLUP; HAK005771; PARK2CRG; PARK2 co-regulated; PARK2 coregulated; parkin coregulated; PACRG2.1 Gene ID 69310 (Mouse); 499021 (Rat) Uniprot ID Related Products christian schools near kingsport tnWebConsequently, of pyrimidine genetic inactivation of tract-binding DJ-1 is found protein-associated to be associated sp to early ing factoronset [35].PD [6] and down-regulation Therefore, upregulation of of DJ-1 DJ-1 isis seen in brainstoofbe considered sporadic PD pa-beneficial for the da tientsnigrostriatum aged [36]. christian schools near fort mill scWeb11 Jun 2024 · The majority of cases of PD appear to be sporadic ( Petit et al., 2005 ) however rare monogenic forms of the disease are useful in gaining a greater understanding of the underlying mechanisms involved in the pathogenesis of PD. Mutations in the parkin gene, located on chromosome 6q25–27, are the most common genetic cause of early … georgia tire recycling center